Casa Editrice:SPRINGER VERLAG
Autori : Lane Emma L., Dunnett Stephen B.
Volume:1
Anno Edizione:2012
ISBN:9781617792977
Categoria:NEUROANATOMIA
Numero Pagine:447
Rilegatura:Rilegato
Formato:25x31
Prezzo Copertina: € 119.35

 

Descrizione

Serves as a comprehensive and valuable reference for those studying motor disorders
Provides appropriate models and assessment tools
Includes clear, easy to follow methods with expert implemenation advice
Movement is the way that animals interact with their environment and is under the organization and complex control of the brain and spinal cord. Multiple central nervous systems, including cortex, basal ganglia, cerebellum, and brainstem, interact to provide precise motor control and integration. Damage or disease within these systems cause profound motor disturbances in man, which can be effectively modeled in animals to develop a better understanding and treatment of the human condition. Animal Models of Movement Disorders introduces a variety of methods and techniques used to model and assess motor function in experimental animals from lower orders, such as drosophila and c. elegans, through vertebrate species including fish, to mammals, such as rodents and non-human primates. The most advanced contemporary models in each system are presented at multiple levels of analysis from molecular and genetic modeling, lesions, anatomy, neurochemistry, to imaging and behavior. Volume I contains general methods of movement disorder assessment as well as an extensive section on dopamine systems.



Comprehensive and meticulous, Animal Models of Movement Disorders serves as a valuable reference for those studying motor disorders by covering methodologies in detail and providing the information necessary to consider both the appropriate models and assessment tools that can most informatively answer the key experimental issues in the field.
Content Level » Professional/practitioner

Keywords » Assessment methods - Behavioral assessments - Central nervous system - Data interpretation - Dopamine systems - Genetic manipulations - Imaging techniques - Motor dysfunction

Related subjects » Animal Sciences - Neurology - Neuroscience

TABLE OF CONTENTS
Part I: Generic Methods of Assessment



1. Why Can’t a Rodent Be More like a Man?: A Clinical Perspective

Anne E. Rosser



2. Zebrafish as a Vertebrate Model Organism for Studying Movement Disorders

Maria Sundvik and Pertti Panula



3. Methodological Strategies to Evaluate Functional Effectors Related to Parkinson’s Disease through Application of C. elegans Models

Kim A. Caldwell and Guy A. Caldwell



4. Effects of Alpha-Synuclein Expression on Behavioral Activity in Drosophila, a Simple Model of Parkinson’s Disease

Robert G. Pendleton, Xiaoyun C. Yang, Natalie Jerome, Ornela Dervisha, and Ralph Hillman



5. Neurological Evaluation of Movement Disorders in Mice

Simon Brooks



6. Rodent Skilled Reaching for Modeling Pathological Conditions of the Human Motor System

Jenni M. Karl and Ian Q. Whishaw



7. High Throughput Mouse Phenotyping

Sabine M. Hölter and Lisa Glasl



8. MRI of Neurological Damage in Rats and Mice

Mathias Hoehn



9. Quantification of Brain Function and Neurotransmission System In Vivo by Positron Emission Tomography: A Review of Technical Aspects and Practical Considerations in Preclinical Research

Nadja Van Camp, Yann Bramoullé, and Philippe Hantraye



10. Optical Approaches to Studying the Basal Ganglia

Joshua L. Plotkin, Jaime N. Guzman, Nicholas Schwarz, Geraldine Kress,

David L. Wokosin, and D. James Surmeier



11. Electrophysiological Analysis of Movement Disorders in Mice

Shilpa P. Rao, Véronique M. André, Carlos Cepeda, and Michael S. Levine



Part II: Dopamine Systems



12. Genetic Models of Parkinson`s Disease

Ralf Kühn, Daniela Vogt-Weisenhorn, and Wolfgang Wurst



13. 6-OHDA Lesion Models of Parkinson’s Disease in the Rat

Eduardo M. Torres and Stephen B. Dunnett



14. 6-OHDA Toxin Model in Mouse

Gaynor A. Smith and Andreas Heuer



15. Rotation in the 6-OHDA Lesioned Rat

Stephen B. Dunnett and Eduardo M. Torres



16. Of Rats and Patients: Some Thoughts about Why Rats Turn in Circles and Parkinson’s Disease Patients Cannot Move Normally

Gordon W. Arbuthnott



17. Comparing Behavioral Assessment of Sensorimotor Function in Rat and Mouse Models of Parkinson’s Disease and Stroke

Sheila M. Fleming and Timothy Schallert



18. Rodent Models of L-DOPA-Induced Dyskinesia

Hanna S. Lindgren and Emma L. Lane



19. Using the MPTP Mouse Model to Understand Neuroplasticity: A New Therapeutic Target for Parkinson’s Disease?

Giselle M. Petzinger, Beth E. Fisher, Garnik Akopian, Ruth Wood, John P. Walsh, and Michael W. Jakowec



20. The MPTP Treated Primate, with Specific Reference to the Use of the Common Marmoset (C. jacchus)

Michael J. Jackson and Peter Jenner



21. Behavioral Assessment in the African Green Monkey after MPTP Administration

D. Eugene Redmond, Jr.