Casa Editrice:SPRINGER VERLAG
Autori :Itzstein Mark Von
Volume:U
Anno Edizione:2012
ISBN:9783764389260
Categoria:VIROLOGIA
Numero Pagine:178
Rilegatura:Rilegato
Formato:25x31
Prezzo Copertina: € 150.55

 

Descrizione

Covers all relevant aspects of anti-influenza virus drug discovery
Contributions by international leading scientists
A valuable source of information for researchers, clinicians and the pharmaceutical industry
Influenza continues to be an ongoing problem despite the existence of vaccines and drugs. Disease outbreaks can occur relatively quickly as witnessed with the recent emergence of the influenza virus A/H1N1 pandemic. The development of new anti-influenza drugs is thus a major challenge.

This volume describes all aspects of the virus structure and function relevant to infection. The focus is on drug discovery of inhibitors to the enzyme sialidase, which plays a key role in the infectious lifecycle of the virus. Following an overview of the influenza virus, the haemagglutinin, the interactions with the cell receptors and the enzymology of virus sialidase, recent results in drug design are presented. These include a full coverage of the design, synthesis and evaluation of carbohydrate as well as non-carbohydrate influenza virus sialidase inhibitors. Further reviews of the clinical experience with influenza virus sialidase inhibitors and of the development of resistance to these inhibitor drugs complement the topic.

Content Level » Research

Keywords » Avian influenza - Drug design - Infectious diseases - Neuraminidase - Sialic acid - Sialidase inhibitors - Tamiflu - Viral-receptor interaction

Related subjects » Immunology - Internal Medicine - Pharmaceutical Science - Virology